Case Studies

Case Study #1 - Follow the Literature

Case Study #2 - Keep it Simple

DEL BioPharma and an offshore CRO were each engaged to propose an SAR study around a known kinase inhibitor.  The CRO proposed an SAR based upon modifications to the core structural motif and requiring multi-step syntheses for each compound.  DEL BioPharma proposed a systematic evaluation of the substituents around a single core permutation and requiring minimal synthetic modifications for each new compound evolving from a common core structure.  Because the DEL BioPharma proposal allowed a more rapid evaluation of novel structures, this proposal was selected.  Within 3 months, 2  diverse, novel and patentable structural classes were generated with lead molecules from each exhibiting single digit nM potency against the target kinase.

Case Study #3 - Find the Right Talent

Case Study #4 - Efficient CRO/CMO Oversight Requires Chemistry Expertise

Case Study #5 - Keep Timelines Realistic

Case Study #6 - Begin with a Detailed RFP

Case Study #7 - Success Depends on 2-Way Communication