Case Studies
Case Study #1 - Follow the Literature
Case Study #2 - Keep it Simple
Case Study #3 - Find the Right Talent
Case Study #4 - Efficient CRO/CMO Oversight Requires Chemistry Expertise
DEL BioPharma was retained to provide chemistry oversight of a complex multi-step synthesis consisting of:
- 18 Linear synthetic steps
- 22 Total synthetic steps
- Multiple protecting group manipulations
- Use of toxic heavy metal reagents in 3 steps
- A scale-limited Birch reduction
Upon review of the protocols developed during the pilot synthesis, immediate recommendations were made regarding workup and isolation procedures that resulted in an overall doubling of the product yield. Additional modifications and improvements to the chemistry resulted in the following:
- Identification of a new target compound with stronger IP and comparable (if not better) biological properties
- 16 linear synthetic steps
- 18 total synthetic steps
- Minimal use of protecting groups
- No toxic heavy metal reagents
- No Birch reduction
- >90% Reduction in cost of goods
- Incorporation of additional improvements is ongoing
The new target compound is currently entering phase I clinical trials.
Case Study #5 - Keep Timelines Realistic
Case Study #6 - Begin with a Detailed RFP
Case Study #7 - Success Depends on 2-Way Communication
COMMUNICATIONS
COMMUNICATIONS
COMMUNICATIONS
Case Studies
Case Study #1 - Follow the Literature
Case Study #2 - Keep it Simple
Case Study #3 - Find the Right Talent
Case Study #4 - Efficient CRO/CMO Oversight Requires Chemistry Expertise
DEL BioPharma was retained to provide chemistry oversight of a complex multi-step synthesis consisting of:
- 18 Linear synthetic steps
- 22 Total synthetic steps
- Multiple protecting group manipulations
- Use of toxic heavy metal reagents in 3 steps
- A scale-limited Birch reduction
Upon review of the protocols developed during the pilot synthesis, immediate recommendations were made regarding workup and isolation procedures that resulted in an overall doubling of the product yield. Additional modifications and improvements to the chemistry resulted in the following:
- Identification of a new target compound with stronger IP and comparable (if not better) biological properties
- 16 linear synthetic steps
- 18 total synthetic steps
- Minimal use of protecting groups
- No toxic heavy metal reagents
- No Birch reduction
- >90% Reduction in cost of goods
- Incorporation of additional improvements is ongoing
The new target compound is currently entering phase I clinical trials.
Case Study #5 - Keep Timelines Realistic
Case Study #6 - Begin with a Detailed RFP
Case Study #7 - Success Depends on 2-Way Communication
Case Studies
Case Study #1 - Follow the Literature
Case Study #2 - Keep it Simple
Case Study #3 - Find the Right Talent
Case Study #4 - Efficient CRO/CMO Oversight Requires Chemistry Expertise
DEL BioPharma was retained to provide chemistry oversight of a complex multi-step synthesis consisting of:
- 18 Linear synthetic steps
- 22 Total synthetic steps
- Multiple protecting group manipulations
- Use of toxic heavy metal reagents in 3 steps
- A scale-limited Birch reduction
Upon review of the protocols developed during the pilot synthesis, immediate recommendations were made regarding workup and isolation procedures that resulted in an overall doubling of the product yield. Additional modifications and improvements to the chemistry resulted in the following:
- Identification of a new target compound with stronger IP and comparable (if not better) biological properties
- 16 linear synthetic steps
- 18 total synthetic steps
- Minimal use of protecting groups
- No toxic heavy metal reagents
- No Birch reduction
- >90% Reduction in cost of goods
- Incorporation of additional improvements is ongoing
The new target compound is currently entering phase I clinical trials.
Case Study #5 - Keep Timelines Realistic
Case Study #6 - Begin with a Detailed RFP
Case Study #7 - Success Depends on 2-Way Communication
COMMUNICATIONS